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Research of geotechnical methods – Stage research report – Stage C
Staš, Lubomír ; Waclawik, Petr ; Souček, Kamil ; Vavro, Martin ; Kukutsch, Radovan ; Schuchová, Kristýna ; Gong, Libin ; Kubina, Lukáš ; Zajícová, Vendula ; Nohejl, Zdeněk ; Rutar, Tomáš
The main goal of project No. FV20294 (GEOSTAB) was the verification of measured geophysical quantities with data obtained by various geotechnical methods. For this reason, stage C - Research of geotechnical methods was solved in parallel and in close cooperation with stage B - Research of geophysical methods. The geotechnical experiments in situ were carried out in the same localities where geophysical methods were applied. For this purpose, several underground mining workings located in different lithological and geomechanical conditions were selected. Experimental gallery Josef was selected in volcanic rocks, the metamorphic rock mass was represented by underground workings of the former deep uranium mine Rožná and the sedimentary environment was examined in the old slate mine Modrá štola. The stage research report summarizes the results of geotechnical, laboratory and numerical methods from all the mentioned localities.
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Historical Outline of the Evolution of the Methods and Forms of Histological Examination
Bašíková, Jana ; Dohnal, František (advisor) ; Doseděl, Martin (referee)
9. Abstract The purpose of this bachelor thesis is to capture the circumstances of the creation, establishment and gradual development of histological examinations in the context of medical history and the historical development of biological sciences. The content of the thesis is focused on clarification of the conditions of creation - discovery of examinations of histological character as the principal qualitative turn and its progress in the medicinal diagnosis. Further aim of the thesis underlines the clarification of single contributions of the important personalities that led to creation and promotion of the field of histology with impact on Czech (Czechoslovak) medical history. This methodology is linked also to the last objective of this thesis that focuses on capturing of the current state and the spectre of possibilities of histological examinations, the methods in use, and last but not least the position and the purpose of the histological task in the field of modern medicine and its respective areas.
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Historical progress of laboratory research methods, historical progress of biochemical laboratory research methods and contemporary practice in the branch
Pavlíčková, Veronika ; Dohnal, František (advisor) ; Babica, Jan (referee)
Veronika Pavlíčková Historical progress of laboratory research methods, historical progress and the present of biochemical laboratory research methods Bachelor thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Medical Laboratory Technician Background: Object of the work is to catch the circumstances of the origin, establishing and gradual progress of laboratory research methods especially the biochemical ones, in context of medical history and historical progress of nature science cognition. In content, the work concentrates on clarifying of the circumstances of the origin of laboratory research methods as an essential qualitative turn and progress in medical diagnostics. Object of the work is also to clarify the participation of important personalities on the origin and enforcement laboratory research methods, all of this applying on the Czech (Czechoslovak) medical past. In continuity on this methodical process another object of the work is to catch the former status of the biochemical branch more specific, applied methods and at least but not last to specify its part and target in the medicine today. Main findings: An effort to explore a biological human material as an important part of diagnostics accompanies the progress of medicine from the oldest times. The...
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Laboratory examination methods in pregnancy focused on screening of congenital malformations in the fetus
SPOUROVÁ, Jana
In my bachelor´s thesis, I deal with screening examination methods in pregnancy, focusing on revealing the risk of congenital developmental anomalies. It is a complex of examinations combining the laboratory determination of biochemical markers in the maternal serum with parameters of ultrasound screening. In the first and early stages of the second trimester the plasmatic protein A and a free beta sub-unit of chorio gonadotropin is examined. The examination is combined with the ultrasound examination of nuchal translucency. In the second trimester of pregnancy, most often in the 15-17th weeks of the pregnancy it consists of the determination of alfa- fetoprotein and choriogonadotropin, sometimes moreover with the non-conjugated estriol. In the laboratory of the clinical biochemistry Privamed of the Municipal Hospital in Plzeň I measured 60 samples of maternity serum for screening in the first trimester and 60 samples for screening in the second trimester on the Roche Elecsys 2010 appliance. I evaluated all the samples in the co-operation with the laboratory for Genetics Plzeň s.r.o. in Alpha software, processing the entered values of biochemical markers, the values measured by the ultrasound and the clinical data of the patient. Out of 60 samples for the first trimester screening, 2 were positive for trisomy of the 21st chromosome and 1 for trisomy of the 18th chromosome, the remaining 57 were negative. Out of 60 for screening in the second trimester, 3 samples were positive for trisomy of the 21st chromosome and 2 for the defects of the neural tube. The positive screening, however, does not mean the presence of the defect, only the increased risk of occurrence. The woman with the positive result of screening are being offered mostly one of the methods of the prenatal diagnostics, for the performance of which taking the amniotic fluid or chorionic villus is necessary, which is invasive for the woman. Prenatal diagnostics focuses first of all on the determining the karyotype of foetus.
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